The profound effects of chemotherapy on the
combined dynamics of the haematological stem cells and their differentiated
neutrophils are examined. G-CSF is often used to deal with this neutropenia andthe response is highly variable. To shape the neutrophil response to
chemotherapy and G-CSF, periodic parametric resonance is discussed. Periodic
oscillation in neutrophil levels and the sub harmonic 1:2 resonance phenomena
are observed with the assumption of periodic chemotherapy is given. The work is
aim to stimulate further investigations and the practical applications.
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